Description

Boc-D-Lysine(Ip/Cbz) CAS NO 135101-22-3 is a protected derivative of the non-natural D-isomer of the amino acid lysine, featuring orthogonal protecting groups (Boc and Cbz) on its side chain. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, enabling precise control over molecular structure and function. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of novel therapeutic agents, diagnostic tools, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-lysine residues with orthogonal side-chain protection, facilitating complex peptide assembly.
• Pharmaceutical Research: Used in the research and development of peptide-based drugs, hormone analogs, and enzyme inhibitors where structural specificity is paramount.
• Bioconjugation: Serves as a linker or functional handle for attaching peptides to other molecules, such as dyes, polymers, or drug carriers, in bioconjugation chemistry.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships (SAR) of peptides containing modified lysine.
• Proteomics & Biochemical Tools: Used in the synthesis of substrates, inhibitors, or affinity probes for studying enzyme function and protein-protein interactions.
• Fine Chemical Synthesis: Acts as a chiral synthon for the asymmetric synthesis of more complex non-peptide molecules in advanced organic chemistry.

Basic Information

Product Name	Boc-D-Lysine(Ip/Cbz)
CAS No.	135101-22-3
Molecular Formula	C20H30N2O6
Molecular Weight	394.47 g/mol
Synonyms	Nα-Boc-Nε-Cbz-D-lysine; Nα-(tert-Butoxycarbonyl)-Nε-(benzyloxycarbonyl)-D-lysine; Boc-D-Lys(Cbz)-OH; (2R)-6-{[(Benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}hexanoic acid; D-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-; Boc-D-Lys(Z)-OH; tert-Butoxycarbonyl-D-lysine(N-benzyloxycarbonyl)
EINECS	Contact for details

Quality Control

Our Boc-D-Lysine(Ip/Cbz) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality, identity, and purity for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.