Description

Dansylisocyclosporin A is a chemically modified, fluorescently labeled derivative of the potent immunosuppressant Cyclosporin A. This compound is specifically engineered for advanced research applications, offering a critical tool for studying drug-protein interactions, cellular uptake, and localization mechanisms. It is primarily utilized by researchers and scientists in the fields of immunology, pharmacology, and molecular biology for fluorescence-based assays and investigative studies.

Application

• Fluorescence-Based Binding Studies: Used as a high-sensitivity probe for investigating the binding affinity and kinetics of Cyclosporin A with its target proteins, such as cyclophilins.
• Cellular Uptake and Localization Tracking: Enables real-time visualization and tracking of drug distribution within live cells using fluorescence microscopy.
• Biochemical Assay Development: Serves as a key reagent in the development of fluorescence polarization (FP) or fluorescence resonance energy transfer (FRET) assays for high-throughput screening.
• Mechanism of Action Research: Facilitates detailed studies on the immunosuppressive pathways and intracellular trafficking of cyclosporine derivatives.
• Proteomics and Biomarker Discovery: Employed in pull-down assays and other proteomic techniques to identify novel protein interactors.
• Quality Control Reference Standard: Can be used as an analytical reference standard in pharmaceutical R&D for related cyclosporine products.

Basic Information

Product Name	Dansylisocyclosporin A
CAS No.	134998-06-4
Molecular Formula	C68H111N11O13S
Molecular Weight	1306.7 g/mol
Synonyms	N-[[(5-Dimethylamino)-1-naphthalenyl]sulfonyl]isocyclosporin A; Dansyl-Cyclosporin A derivative; Fluorescent Cyclosporin A probe; CsA-Dansyl conjugate; [N-Dansyl]isocyclosporin A; Cyclosporin A dansylamide; 1-[[(5-Dimethylamino)naphthalene-1-sulfonyl]amino]cyclosporin A
EINECS	Contact for details

Quality Control

Our Dansylisocyclosporin A is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our analytical methods, including HPLC and mass spectrometry, are validated to provide reliable data for our global research and pharmaceutical clients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.