Description

4-Fluoro-2-Methyl-5-Nitroanisole is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which makes it a key intermediate for constructing complex molecules with tailored properties. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic cores in electronic and display materials, improving charge transport and thermal stability.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized nitro- and amino-azo dyes, where the fluorine and methoxy groups influence color fastness and hue.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	4-Fluoro-2-Methyl-5-Nitroanisole
CAS No.	134882-63-6
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	5-Nitro-2-methyl-4-fluoroanisole; 1-Fluoro-2-methoxy-4-methyl-5-nitrobenzene; 4-Fluoro-2-methyl-5-nitro-1-methoxybenzene; 2-Methyl-4-fluoro-5-nitroanisole; Benzene, 1-fluoro-2-methoxy-4-methyl-5-nitro-; 4-Fluoro-2-methyl-5-nitroanisole; 2-Methoxy-5-nitro-4-fluorotoluene
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Methyl-5-Nitroanisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly closed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.