Description

3-Hydroxy-3-Methylglutaryldithio-Coenzyme A is a specialized biochemical intermediate crucial for research in metabolic pathways and enzyme kinetics. This compound matters as a key tool for studying the regulation of HMG-CoA metabolism, which is fundamental to cholesterol biosynthesis and isoprenoid production. It is primarily needed by pharmaceutical R&D teams, academic biochemistry laboratories, and diagnostic developers focused on lipid metabolism disorders and drug discovery.

Application

• Biochemical Research: Used as a substrate or intermediate in enzymatic assays to study HMG-CoA lyase and related metabolic enzymes.
• Pharmaceutical Development: Serves as a critical reference standard and building block in the research of novel lipid-lowering agents and metabolic disorder treatments.
• Diagnostic Reagent Manufacturing: Employed in the formulation of test kits for the detection and quantification of specific enzymes or metabolites in clinical samples.
• Enzyme Kinetics Studies: Essential for investigating reaction mechanisms, inhibition constants (Ki), and catalytic efficiency of enzymes in the mevalonate pathway.
• Metabolomics and Pathway Analysis: A valuable analytical standard for mass spectrometry and chromatography in mapping cellular metabolic fluxes.

Basic Information

Product Name	3-Hydroxy-3-Methylglutaryldithio-Coenzyme A
CAS No.	134785-93-6
Molecular Formula	C27H44N7O19P3S2
Molecular Weight	951.77 g/mol
Synonyms	HMG-Dithio-CoA; 3-Hydroxy-3-methylglutaryl-dithio-coenzyme A; 3-Hydroxy-3-methylglutaryl-CoA dithioester; HMG-S-CoA; (R)-3-Hydroxy-3-methylglutaryl-dethia-CoA; Coenzyme A, S-[3-hydroxy-3-methyl-1,3-dioxopentyl)dithio]-; 3-Hydroxy-3-methylglutaryl thioester with Dethia-CoA
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3-Methylglutaryldithio-Coenzyme A is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.