Description

Rasburicase is a recombinant urate-oxidase enzyme used as a critical therapeutic agent. Its primary value lies in the rapid and effective prevention and treatment of tumor lysis syndrome (TLS), a dangerous oncologic emergency, by catalyzing the oxidation of uric acid into a more soluble metabolite. This product is essential for hospitals, oncology clinics, and pharmaceutical manufacturers involved in producing life-saving treatments for patients undergoing chemotherapy for hematologic malignancies. We supply high-purity Rasburicase CAS NO 134774-45-1 to meet the stringent demands of the global biopharmaceutical industry.

Application

• Oncologic Therapeutics: First-line treatment and prophylaxis for hyperuricemia in patients with hematologic cancers at high risk for Tumor Lysis Syndrome (TLS).
• Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) for the formulation of injectable biologic drugs.
• Clinical & Hospital Use: Administration in inpatient and outpatient settings to manage uric acid levels prior to and during chemotherapy induction.
• Biosimilar Development: Reference standard or key component in the research and development of biosimilar versions of urate-oxidase therapies.
• Research & Diagnostic Use: Biochemical reagent in enzymatic assays and research studies focused on purine metabolism and related disorders.

Basic Information

Item	Detail
Product Name	Rasburicase
CAS No.	134774-45-1
Molecular Formula	C1523H2414N420O472S14
Molecular Weight	~34 kDa
Synonyms	Urate Oxidase, Recombinant Uricase; Uricase; SR 29142; Fasturtec (trade name); Elitek (trade name); Rasburicase recombinant; Uric acid oxidase
EINECS	Contact for details

Quality Control

Our Rasburicase is manufactured under strict quality systems. Each batch is subjected to a comprehensive battery of tests including purity by HPLC, potency (specific activity) assay, and analysis for process-related impurities to ensure it meets the rigorous standards for biopharmaceutical APIs. Certificates of Analysis (COA) detailing identity, purity, sterility (where applicable), and endotoxin levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Under these conditions, the product is stable for extended periods. This material is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE & HPLC)	≥ 98.0%
Specific Activity	≥ 8 U/mg protein
Protein Content (UV)	90 - 110% of label claim
Endotoxin	< 1.0 EU/mg
Residual Host Cell DNA	< 10 pg/mg
Residual Host Cell Protein	< 100 ppm
Moisture (KF)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.