Description

6-(Iodoacetamido)Caproic Acid n-Hydroxysuccinimide is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a thiol-reactive iodoacetamide group. This compound is essential for creating stable, covalent linkages between proteins, peptides, and other biomolecules, enabling advanced bioconjugation strategies. It is primarily used by researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and proteomics research to develop antibody-drug conjugates (ADCs), enzyme immobilization matrices, and labeled probes.

Application

• Bioconjugation and Crosslinking: For site-specific conjugation of peptides, proteins, and antibodies, particularly in the synthesis of antibody-drug conjugates (ADCs).
• Diagnostic Reagent Manufacturing: Used to label antibodies or enzymes with reporter molecules (e.g., fluorophores, enzymes) for ELISA, lateral flow assays, and other immunoassays.
• Proteomics Research: A key tool for protein-protein interaction studies, protein labeling, and the preparation of affinity chromatography resins.
• Surface Immobilization: Functionalization of solid supports (e.g., beads, chips, plates) for immobilizing biomolecules while maintaining activity.
• Biomaterial Engineering: Modification of polymers or hydrogels to introduce bioactive ligands for tissue engineering and drug delivery systems.
• Chemical Biology Probes: Synthesis of activity-based probes for studying enzyme function and cellular pathways.

Basic Information

Item	Detail
Product Name	6-(Iodoacetamido)Caproic Acid n-Hydroxysuccinimide
CAS No.	134759-23-2
Molecular Formula	C13H18IN2O6
Molecular Weight	425.10 g/mol
Synonyms	6-((Iodoacetyl)amino)hexanoic Acid N-Hydroxysuccinimide Ester; Iodoacetyl-LC-NHS; NHS-Iodoacetamide-LC; N-Succinimidyl 6-((Iodoacetyl)amino)hexanoate; IAA-LC-NHS; Iodoacetamido-Caproyl-NHS; 6-(Iodoacetamido)hexanoic Acid NHS Ester; N-(6-(2,5-Dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)iodoacetamide
EINECS	Contact for details

Quality Control

Our 6-(Iodoacetamido)Caproic Acid n-Hydroxysuccinimide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant standards for research and in-vitro diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is strictly light-sensitive and hygroscopic. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMF, DMSO, acetonitrile
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.