Description

β-Amyloid (12-20) is a synthetic peptide fragment corresponding to residues 12-20 of the amyloid-beta protein. This specific sequence is a critical research tool for studying the aggregation mechanisms, structural properties, and neurotoxicity associated with Alzheimer's disease pathology. It is essential for academic, pharmaceutical, and biotechnology laboratories focused on neurodegenerative disease research and therapeutic development. The compound is supplied as a high-purity material to ensure reliable and reproducible experimental results.

Application

• Biochemical Research: Fundamental studies on amyloid-beta peptide aggregation kinetics and fibril formation.
• Drug Discovery Screening: Used as a target or inhibitor in high-throughput assays to identify potential therapeutic compounds for Alzheimer's disease.
• Antibody Development & Epitope Mapping: Serves as a key antigen for generating and characterizing antibodies specific to the mid-domain region of amyloid-beta.
• Structural Biology: NMR and X-ray crystallography studies to determine the three-dimensional conformation of amyloid-beta fragments.
• Toxicity Assays: Evaluation of cellular and synaptic toxicity mechanisms in neuronal cell culture models.
• Diagnostic Reagent Development: Component in the development of immunoassays and biosensors for detecting amyloid-beta derivatives.

Basic Information

Product Name	β-Amyloid (12-20)
CAS No.	134649-29-9
Molecular Formula	C45H68N12O13
Molecular Weight	961.1 g/mol
Synonyms	Amyloid β-Protein (12-20); Aβ (12-20); β-Amyloid (12-20); Amyloid β-Peptide (12-20); H-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-OH; VHHQKLVFF; Amyloidogenic Peptide (12-20)
EINECS	Contact for details

Quality Control

Every batch of β-Amyloid (12-20) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), peptide content, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water, DMSO, or acetonitrile/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.