Description

Dynorphin A (1-13), Tyr(14)-Leu(15)-Phe(16)-Asn(17)-Gly(18)-Pro(19)- CAS NO 134646-23-4 is a synthetic peptide fragment of the endogenous opioid peptide Dynorphin A, specifically comprising residues 1 through 13 with an extended sequence. This compound is a critical research tool for investigating the κ-opioid receptor (KOR) system, which plays a significant role in pain modulation, stress responses, and reward pathways. It is essential for pharmaceutical R&D, academic neuroscience research, and biochemical studies focused on neuropeptide signaling and receptor-ligand interactions.

Application

• Neuroscience Research: As a selective κ-opioid receptor (KOR) agonist for studying pain pathways, addiction mechanisms, and stress-related behaviors.
• Pharmacological Studies: Used in vitro and in vivo to characterize receptor binding affinity, signal transduction, and physiological effects of dynorphin peptides.
• Biochemical Assay Development: Serves as a reference standard or active component in assays for screening potential KOR-targeting therapeutics.
• Neuropharmacology: Investigation of the role of endogenous opioid systems in mood disorders, neuroprotection, and analgesia.
• Peptide Chemistry & Conjugation: Used as a starting material or template for developing labeled (e.g., fluorescent, radioactive) peptide analogs for imaging and tracing studies.
• Academic & Institutional Research: Fundamental research in universities and institutes exploring neuropeptide function and central nervous system biology.

Basic Information

Product Name	Dynorphin A (1-13), Tyr(14)-Leu(15)-Phe(16)-Asn(17)-Gly(18)-Pro(19)- CAS NO 134646-23-4
CAS No.	134646-23-4
Molecular Formula	C81H121N21O20
Molecular Weight	1660.96 g/mol
Synonyms	Dynorphin A (1-13) amide; Dynorphin A (1-13)-NH2; [Tyr14, Leu15, Phe16, Asn17, Gly18, Pro19]Dynorphin A (1-13) amide; Dynorphin A Fragment 1-13 amide; Dynorphin A (1-13) extended; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Tyr-Leu-Phe-Asn-Gly-Pro-NH2
EINECS	Contact for details

Quality Control

Our Dynorphin A (1-13) peptide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation, ensuring it meets the high standards required for critical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and solvent residues.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.