Description

(S)-A-Hydroxy-2-Thiopheneacetonitrile is a high-value chiral building block and key synthetic intermediate in advanced organic chemistry. Its core value lies in its stereochemically defined structure, which is essential for creating enantiomerically pure compounds with specific biological activity. This product is critically needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical purity.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the development of new asymmetric catalytic reactions and methodologies.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of complex fine chemicals, flavors, and fragrances that require precise molecular architecture.
• Material Science Precursor: Acts as a specialized monomer or building block for novel polymers and advanced organic materials with tailored properties.

Basic Information

Product Name	(S)-A-Hydroxy-2-Thiopheneacetonitrile
CAS No.	134562-59-7
Molecular Formula	C7H7NOS
Molecular Weight	153.20 g/mol
Synonyms	(S)-(-)-2-Hydroxy-2-(2-thienyl)acetonitrile; (S)-2-Hydroxy-2-(thiophen-2-yl)acetonitrile; (S)-α-Hydroxy-2-thiopheneacetonitrile; (S)-2-Thienylglycolonitrile; (S)-Hydroxy(thiophen-2-yl)acetonitrile; (2S)-2-Hydroxy-2-(thiophen-2-yl)acetonitrile; (S)-2-(2-Hydroxy-2-cyanoethyl)thiophene
EINECS	Contact for details

Quality Control

Our (S)-A-Hydroxy-2-Thiopheneacetonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC/MS to confirm identity, purity, and optical rotation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Optical Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.