Description

β-Amyloid (1-43) is a specific 43-amino acid peptide fragment of the amyloid precursor protein (APP), a key biomarker and research target in the study of neurodegenerative diseases. This peptide is crucial for investigating the molecular mechanisms of amyloid plaque formation and neurotoxicity, which are central to conditions like Alzheimer's disease. It is an essential biochemical tool for researchers and developers in neuroscience, pharmaceutical R&D, and diagnostic assay development, providing a defined substrate for studying aggregation kinetics, screening therapeutic compounds, and validating detection methods.

Application

• Neuroscience Research: Fundamental studies on the aggregation, toxicity, and clearance mechanisms of amyloid-beta peptides.
• Drug Discovery & Screening: Used as a target substrate in high-throughput assays to identify and evaluate potential inhibitors of amyloid-beta aggregation or oligomerization.
• Biomarker & Diagnostic Development: Serves as a critical standard or antigen in the development and calibration of immunoassays (ELISA, Western Blot) and biosensors for detecting amyloid-beta variants in biological samples.
• Toxicology Studies: Investigation of the cellular and molecular pathways of neurotoxicity induced by different amyloid-beta isoforms.
• Biophysical Characterization: Analysis of peptide structure, stability, and aggregation propensity using techniques like spectroscopy, chromatography, and electron microscopy.
• Antibody Production & Validation: Acts as an immunogen for generating specific antibodies or as a reference standard for testing antibody specificity and affinity.

Basic Information

Product Name	β-Amyloid (1-43)
CAS No.	134500-80-4
Molecular Formula	C206H317N55O58S
Molecular Weight	4654.2 g/mol
Synonyms	Amyloid β-Protein (1-43); Aβ1-43; Aβ43; Amyloid β-Peptide (1-43); β-Amyloid Peptide (1-43); APP (672-714); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
EINECS	Contact for details

Quality Control

Our β-Amyloid (1-43) is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) upon request, supporting research that demands reliable and well-defined biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in 1% NH₄OH or DMSO
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.