Description

(S)-2-Diphenyphosphino-2'-Methoxyl-1,1'-Binaphthyl CAS NO 134484-36-9 is a high-value, chiral monophosphine ligand belonging to the MOP (Methoxy-substituted Phosphine) family, renowned for its excellent enantioselectivity in asymmetric catalysis. Its core value lies in enabling the synthesis of chiral molecules with high optical purity, which is critical for developing advanced pharmaceuticals and fine chemicals. This ligand is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance catalysts for challenging asymmetric transformations.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral intermediates for active pharmaceutical ingredients (APIs).
• Asymmetric Cross-Coupling Reactions: Employed in palladium-catalyzed reactions such as Suzuki-Miyaura and Heck couplings to construct chiral biaryl axes with high enantiomeric excess.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral building blocks used in the manufacture of drugs for central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic and Industrial R&D: A valuable tool for methodology development in academic laboratories and for scaling up novel catalytic processes in industrial settings.
• Fine Chemical Production: Facilitates the synthesis of chiral flavors, fragrances, and advanced materials with specific stereochemical properties.

Basic Information

Product Name	(S)-2-Diphenyphosphino-2'-Methoxyl-1,1'-Binaphthyl
CAS No.	134484-36-9
Molecular Formula	C33H25OP
Molecular Weight	468.52 g/mol
Synonyms	(S)-MOP; (S)-2-(Diphenylphosphino)-2'-methoxy-1,1'-binaphthyl; (S)-2-Methoxy-2'-(diphenylphosphino)-1,1'-binaphthyl; (S)-2'-Methoxy-2-(diphenylphosphino)-1,1'-binaphthalene; (S)-2-(Diphenylphosphanyl)-2'-methoxy-1,1'-binaphthyl; (S)-(-)-2-Diphenylphosphino-2'-methoxy-1,1'-binaphthyl; (S)-MOP Ligand; (S)-Binaphthol MOP
EINECS	Contact for details

Quality Control

Our (S)-2-Diphenyphosphino-2'-Methoxyl-1,1'-Binaphthyl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is paramount for catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (ee%), and identity is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or light should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.