Description

D-Proline, 1-(Trifluoroacetyl)- (9Ci) is a high-purity, non-natural amino acid derivative featuring a trifluoroacetyl protecting group on the nitrogen of the proline ring. This compound is a critical chiral building block in advanced organic synthesis, particularly for the preparation of peptides and peptidomimetics with enhanced metabolic stability. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require enantiomerically pure intermediates for drug discovery and development processes. The product is supplied with full analytical documentation to ensure batch-to-batch consistency and support rigorous quality standards.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for protease inhibitors and other peptide-based therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected D-proline derivative to introduce conformational constraints.
• Medicinal Chemistry Research: Serves as a building block for creating focused libraries of novel compounds in drug discovery programs targeting various diseases.
• Bioconjugation: Can be utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugates where a stable, non-natural amino acid linker is required.
• Asymmetric Synthesis: Acts as a chiral auxiliary or catalyst precursor in stereoselective organic transformations.
• Agrochemical Research: Employed in the research and development of novel, enantiomerically pure agrochemicals.

Basic Information

Product Name	D-Proline, 1-(Trifluoroacetyl)- (9Ci)
CAS No.	134454-19-6
Molecular Formula	C7H8F3NO3
Molecular Weight	211.14 g/mol
Synonyms	(R)-1-(Trifluoroacetyl)pyrrolidine-2-carboxylic acid; D-1-Trifluoroacetylproline; (R)-N-(Trifluoroacetyl)proline; (R)-2-Pyrrolidinecarboxylic acid, 1-(trifluoroacetyl)-; N-Trifluoroacetyl-D-proline; 1-Trifluoroacetyl-D-proline; D-Proline, N-trifluoroacetyl-; TFA-D-Proline-OH
EINECS	Contact for details

Quality Control

Our D-Proline, 1-(Trifluoroacetyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.