Description

(S)-2-Hydroxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value chiral piperidine derivative and a crucial protected intermediate in organic synthesis. This compound matters for its role in constructing complex molecules with precise stereochemistry, enabling the development of advanced pharmaceuticals and bioactive compounds. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral active pharmaceutical ingredients (APIs), particularly in neurological and antiviral drug candidates.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in stereoselective reactions to create enantiomerically pure compounds.
• Medicinal Chemistry Research: Used in the discovery and optimization of new drug molecules, especially those targeting G-protein coupled receptors (GPCRs).
• Peptidomimetics: Integral component in the design and synthesis of peptide analogs and conformationally restricted scaffolds.
• Agrochemical Synthesis: Intermediate for developing chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Precursor for creating novel chiral ligands used in homogeneous catalysis.

Basic Information

Product Name	(S)-2-Hydroxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	134441-93-3
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	(S)-1-Boc-2-(Hydroxymethyl)piperidine; (S)-N-Boc-2-Piperidinemethanol; (S)-2-(Hydroxymethyl)-1-(tert-Butoxycarbonyl)piperidine; (S)-1-(tert-Butoxycarbonyl)-2-piperidinemethanol; (S)-tert-Butyl 2-(hydroxymethyl)piperidine-1-carboxylate; (S)-N-Boc-2-(Hydroxymethyl)piperidine; (S)-2-Piperidinemethanol, 1-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our (S)-2-Hydroxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Enantiomeric Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.