Description

Diiodo-Philanthotoxin-343-Arginine is a chemically modified analog of the potent neurotoxin philanthotoxin, specifically engineered for advanced neuroscience and pharmacological research. This compound is valued for its high-affinity antagonistic activity at ionotropic glutamate receptors, particularly AMPA and kainate subtypes, making it a critical tool for studying synaptic transmission and neurological disorders. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuropharmacology, ion channel research, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and modulation of ionotropic glutamate receptors (iGluRs) in neuronal circuits.
• Ion Channel Pharmacology: Used to investigate the structure-activity relationships (SAR) of AMPA and kainate receptor antagonists.
• Drug Discovery: Serves as a reference compound or lead structure in the development of new neuroprotective agents or treatments for excitotoxicity-related conditions.
• Biochemical Assays: Employed in in vitro binding studies and functional assays to characterize receptor-ligand interactions.
• Toxicology Studies: Used to model and understand the mechanisms of neuroactive toxins and their effects on synaptic communication.

Basic Information

Product Name	Diiodo-Philanthotoxin-343-Arginine
CAS No.	134419-06-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Diiodo-PhTX-343-Arg; Arg-Diiodo-PhTX-343; Philanthotoxin-343 diiodo arginine analog; Glutamate receptor antagonist analog; Non-competitive AMPA receptor blocker; Neurotoxin research analog; iGluR antagonist research chemical
EINECS	Contact for details

Quality Control

Our Diiodo-Philanthotoxin-343-Arginine is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to high-purity standards typical for research-grade biochemicals, ensuring the integrity of your experimental data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept under desiccant. For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.