Description

Threonine, L-, [3H(G)] is a tritium-labeled form of the essential amino acid L-Threonine, specifically designed for advanced research applications. This high-specific-activity compound is critical for metabolic pathway tracing, protein turnover studies, and pharmacokinetic research where precise isotopic labeling is required. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in life science and biochemical research.

Application

• Biochemical Research & Metabolic Studies: Used as a tracer to investigate amino acid metabolism, protein synthesis, and degradation pathways in biological systems.
• Pharmaceutical Development: Employed in ADME (Absorption, Distribution, Metabolism, and Excretion) studies for drug candidates that interact with amino acid pathways.
• Nutritional Science Research: Facilitates studies on amino acid uptake, utilization, and requirements in animal and human models.
• Proteomics & Protein Labeling: Serves as a precursor for the biosynthesis of labeled proteins for structural and functional analysis.
• Enzyme Kinetics & Mechanism Studies: Acts as a substrate or inhibitor in assays to elucidate enzyme function and kinetics.
• Cell Culture & Media Supplementation Studies: Used in specialized cell culture applications to track nutrient incorporation.

Basic Information

Product Name	Threonine, L-, [3H(G)]
CAS No.	134357-96-3
Molecular Formula	C₄H₇⁺HₓNO₃ (x indicates position of tritium label)
Molecular Weight	~121.1 g/mol (varies with specific activity)
Synonyms	(2S,3R)-2-Amino-3-hydroxybutanoic acid, tritiated; L-Threonine (tritiated); [G-³H]-L-Threonine; Tritium-labeled L-Threonine; (2S,3R)-2-Azaniumyl-3-hydroxybutanoate-³H; Threonine-³H; Radioactive L-Threonine
EINECS	Contact for details

Quality Control

Every batch of Threonine, L-, [3H(G)] is manufactured and analyzed under strict quality systems. Product specifications include rigorous testing for radiochemical purity (typically by HPLC), specific activity (Ci/mmol or GBq/mmol), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing the analytical results, including solvent composition and expiration date, is provided with each shipment to ensure traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is light-sensitive (store away from light) and highly volatile in its radioactive form; appropriate containment and laboratory ventilation are required. Users must adhere to all local and international regulations for the safe handling, storage, and disposal of radioactive materials.

Specification

Item	Specification
Appearance	Clear colorless to slightly yellow solution
Identification (HPLC, TLC)	Conforms to standard
Specific Activity	Customizable (e.g., 10-100 Ci/mmol)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water mixture or as specified
Concentration	1 mCi/mL (typical, customizable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.