Description

3-Oxo-1-(Phenylamino)-4,4,4-Trifluorobut-1-Ene is a specialized trifluoromethylated enaminone building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile precursor in the development of pharmaceuticals and agrochemicals, where the introduction of the trifluoromethyl group is crucial for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex heterocycles and active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF₃ group enhances product performance and environmental profile.
• Heterocyclic Chemistry: A fundamental building block for constructing various nitrogen and oxygen-containing heterocycles, such as pyrazoles, isoxazoles, and pyrimidines, via cyclocondensation reactions.
• Material Science Precursor: Investigated for the synthesis of advanced organic materials, including liquid crystals and polymers with unique electronic or optical properties.
• Fluorine Chemistry Studies: An important substrate for studying the reactivity and applications of fluorinated enaminones in synthetic methodology development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	3-Oxo-1-(Phenylamino)-4,4,4-Trifluorobut-1-Ene
CAS No.	134219-71-9
Molecular Formula	C₁₀H₈F₃NO
Molecular Weight	215.17 g/mol
Synonyms	4,4,4-Trifluoro-3-oxo-1-(phenylamino)but-1-ene; 1-Phenylamino-4,4,4-trifluoro-3-buten-2-one; 3-Buten-2-one, 4,4,4-trifluoro-1-(phenylamino)-; (Z)-4,4,4-Trifluoro-3-oxo-1-(phenylamino)but-1-ene; N-Phenyl-4,4,4-trifluoro-3-oxobut-1-en-1-amine; Trifluoromethylated enaminone; 3-Oxo-1-(phenylamino)-4,4,4-trifluorobut-1-ene
EINECS	Contact for details

Quality Control

Our 3-Oxo-1-(Phenylamino)-4,4,4-Trifluorobut-1-Ene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.