Description

Synaptotagmin is a critical calcium-binding protein that plays a fundamental role in the regulation of synaptic vesicle exocytosis and neurotransmitter release. Its importance lies in its function as the primary calcium sensor for fast, synchronous synaptic transmission in neurons. This makes it an essential research reagent for neuroscientists, molecular biologists, and pharmaceutical developers studying synaptic function, neurological disorders, and potential therapeutic targets.

Application

• Neuroscience Research: Fundamental studies on the molecular mechanisms of synaptic vesicle fusion, neurotransmitter release, and synaptic plasticity.
• Drug Discovery & Target Validation: Used as a target protein in high-throughput screening assays to identify novel compounds for neurological and psychiatric conditions.
• Biochemical Assay Development: Serves as a key component in in vitro reconstitution assays to study protein-protein interactions within the synaptic vesicle release machinery.
• Cell Biology Studies: Investigation of intracellular membrane trafficking, calcium signaling pathways, and exocytosis in various cell types.
• Diagnostic Tool Development: Potential use in developing assays for autoantibodies associated with paraneoplastic neurological syndromes.
• Academic & Institutional Research: Essential reagent for universities and research institutes focused on neurobiology, cell signaling, and membrane biology.

Basic Information

Product Name	Synaptotagmin
CAS No.	134193-27-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Synaptotagmin I; Syt I; p65; Calcium-dependent membrane-binding protein; Synaptotagmin-1; SYT1; SYT; Synaptotagmin Cytoplasmic Domain; Synaptotagmin C2AB domain
EINECS	Contact for details

Quality Control

Our Synaptotagmin is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is subjected to rigorous analytical testing, including purity assessment and functional validation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, concentration, and biological activity is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (SDS-PAGE / Mass Spec)	Conforms
Purity (SDS-PAGE / HPLC)	> 95%
Protein Concentration	As per COA (typically 0.1 - 1.0 mg/mL)
Biological Activity (Lipid Binding Assay)	Calcium-dependent
Endotoxin Level (LAL Test)	< 1.0 EU/μg
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.