Description

Acetylcholine Receptor α-Subunit (125-148) is a synthetic peptide fragment corresponding to a specific extracellular region of the nicotinic acetylcholine receptor (nAChR) alpha subunit. This high-purity biochemical is a critical research tool for investigating receptor structure, function, and the molecular basis of neurological signaling and autoimmune disorders. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers working in neuroscience, immunology, and drug discovery.

Application

• Antigen for Antibody Production: Used as an immunogen to generate polyclonal or monoclonal antibodies specific to the nAChR α-subunit for research and diagnostic assays.
• Neurological Research: Serves as a key reagent in binding studies, competitive inhibition assays, and structure-activity relationship (SAR) studies to understand ligand-receptor interactions.
• Autoimmune Disease Studies: Employed in research on Myasthenia Gravis (MG) to study the role of nAChR epitopes in autoimmune antibody response and pathogenesis.
• Diagnostic Development: Acts as a coating antigen or competitor in ELISA and other immunoassay formats for the detection of anti-nAChR autoantibodies in patient sera.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel compounds that modulate the acetylcholine receptor.
• Biomarker Research: Facilitates the study of receptor alterations and epitope mapping in various neurological conditions and cancers.

Basic Information

Product Name	Acetylcholine Receptor α-Subunit (125-148)
CAS No.	134152-16-2
Molecular Formula	C116H190N38O33S2
Molecular Weight	2637.1 g/mol
Synonyms	nAChR α-subunit (125-148); Acetylcholine Receptor Protein, alpha Chain (125-148); AChR-alpha (125-148); Nicotinic Acetylcholine Receptor Alpha 1 Subunit Peptide (125-148); α-Bungarotoxin Binding Site Peptide; VIVKLLLPLTISLLLIPVSIYR; Myasthenia Gravis Antigen Peptide; Synthetic nAChR Epitope
EINECS	Contact for details

Quality Control

Every batch of Acetylcholine Receptor α-Subunit (125-148) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency. Our quality system employs advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, sequence verification (MS/MS), and endotoxin levels is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This peptide is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to minimize freeze-thaw cycles and maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Sequence	VIVKLLLPLTISLLLIPVSIYR
Molecular Weight	2637.1 ± 1.0 Da
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.