Description

Boc-D-4-Thiazolylalanine CAS NO 134107-69-0 is a high-purity, non-natural amino acid derivative featuring a thiazole side chain protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling advanced research in medicinal chemistry and drug discovery. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutics, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of bioactive peptides and peptidomimetic drug candidates.
• Protease Inhibitor Development: Used in constructing novel scaffolds for inhibitors targeting specific proteases, leveraging the unique electronic properties of the thiazole ring.
• Chemical Biology Research: Incorporation into peptide probes and substrates to study enzyme mechanisms, protein-protein interactions, and cellular signaling pathways.
• Agrochemical Research: Serves as a building block for developing novel peptide-based agrochemicals with potential insecticidal or fungicidal activity.
• Material Science: Potential use in creating functionalized polymers and advanced materials with specific molecular recognition properties.

Basic Information

Product Name	Boc-D-4-Thiazolylalanine
CAS No.	134107-69-0
Molecular Formula	C11H16N2O4S
Molecular Weight	272.32 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid; Boc-D-4-Thiazolyl-Ala-OH; Boc-D-Thz(4)-OH; N-(tert-Butoxycarbonyl)-D-4-thiazolylalanine; D-2-[(tert-Butoxycarbonyl)amino]-3-(1,3-thiazol-4-yl)propanoic acid; Boc-D-Thz-OH; N-Boc-4-thiazolyl-D-alanine; Boc-D-β-(4-Thiazolyl)-alanine
EINECS	Contact for details

Quality Control

Our Boc-D-4-Thiazolylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.