Description

Fmoc-D-Asp-Otbu CAS NO 134098-70-7 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its value lies in providing stereochemical control and side-chain protection for the aspartic acid residue, preventing unwanted side reactions during complex peptide assembly. This compound is critically needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries for the development of therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of D-aspartic acid into peptide chains.
• Pharmaceutical Intermediate: For the research and production of novel therapeutic peptides and peptidomimetics.
• Bioconjugation: Used in the synthesis of peptide-based conjugates for drug delivery systems and diagnostic agents.
• Chemical Biology Research: A crucial reagent for studying protein-protein interactions and enzyme mechanisms.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening of bioactive peptide sequences.
• API Development: Serves as an advanced intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs) containing non-natural amino acids.

Basic Information

Product Name	Fmoc-D-Asp-Otbu
CAS No.	134098-70-7
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	Fmoc-D-aspartic acid β-tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-aspartic acid 4-tert-butyl ester; Fmoc-D-Asp(OtBu)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)succinic acid 4-tert-butyl ester; Fmoc-D-Aspartic acid 4-tert-butyl ester; N-Fmoc-D-aspartic acid β-tert-butyl ester; Fmoc-D-Asp(OBut)-OH; tert-Butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-aspartate
EINECS	Contact for details

Quality Control

Our Fmoc-D-Asp-Otbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.