Description

Nartograstim CAS NO 134088-74-7 is a recombinant human granulocyte colony-stimulating factor (G-CSF) analog, engineered for enhanced stability and biological activity. This pharmaceutical-grade compound is critical for stimulating the production of neutrophils, a vital component of the immune system. It is primarily utilized in the biopharmaceutical industry for the development of advanced therapeutics targeting neutropenia, a condition often associated with chemotherapy, and for supporting patients undergoing bone marrow transplantation.

Application

• Oncology Supportive Care: Prevention and treatment of chemotherapy-induced neutropenia to reduce the risk of infection.
• Hematopoietic Stem Cell Transplantation: Mobilization of peripheral blood progenitor cells (PBPCs) for collection and subsequent transplantation.
• Severe Chronic Neutropenia (SCN): Long-term management of congenital, cyclic, or idiopathic neutropenia to increase neutrophil counts.
• Research & Development: Used as a reference standard or active ingredient in preclinical and clinical studies for novel immunotherapies.
• Biosimilar Development: Serves as a key intermediate or reference molecule for the formulation and analytical testing of biosimilar G-CSF products.
• Drug Delivery Systems: Incorporated into advanced delivery platforms like sustained-release formulations to improve patient compliance.

Basic Information

Product Name	Nartograstim
CAS No.	134088-74-7
Molecular Formula	C845H1343N223O243S9
Molecular Weight	Approx. 18,800 Da
Synonyms	KW-2228; Recombinant Human G-CSF (174-amino acid variant); Granulocyte Colony-Stimulating Factor (des-Ala1-Leu2-Gly3-Pro4-Gln5-Thr6, Arg23, Leu25, Tyr144, Ala145, Pro146, Ser147); rHuG-CSF (Nartograstim); G-CSF Analog KW2228; Filgrastim analog; Lenograstim-related protein
EINECS	Contact for details

Quality Control

Our Nartograstim is manufactured under strict quality systems. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and safety, aligning with ICH Q6B guidelines for biotechnological products. A Certificate of Analysis (COA) detailing specifications for purity (by HPLC), biological activity (cell-based proliferation assay), endotoxin levels, and related proteins is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. For long-term storage, maintain at -70°C or lower. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Bioassay)	Stimulates NFS-60 cell proliferation
Purity (RP-HPLC)	≥ 98.0%
Related Proteins (SE-HPLC)	≤ 2.0%
Potency	90% - 110% of labeled activity
Endotoxin	< 1.0 EU/μg
Moisture Content (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.