Description

Pleiotrophin CAS NO 134034-50-7 is a secreted, heparin-binding cytokine and growth factor, also known as heparin-binding growth-associated molecule (HB-GAM). This protein plays a crucial role in regulating cell growth, differentiation, and migration, making it a vital research tool in developmental biology and oncology. It is primarily utilized by biotechnology and pharmaceutical R&D teams for studying neural development, angiogenesis, and tumor progression mechanisms.

Application

• Biomedical Research: Fundamental studies in neurobiology, angiogenesis, and tissue regeneration.
• Drug Discovery & Development: Target validation and screening for therapeutic agents in oncology and neurodegenerative diseases.
• Cell Culture & Assay Development: Used as a critical reagent in cell-based assays to study signaling pathways.
• Diagnostic Reagent Manufacturing: Component in the development of ELISA kits and other diagnostic tools for research purposes.
• Academic Research: Essential for university and institutional labs focusing on growth factor biology and cancer research.

Basic Information

Product Name	Pleiotrophin
CAS No.	134034-50-7
Molecular Formula	CnHmNoOpSq (Contact for details)
Molecular Weight	Contact for details
Synonyms	Heparin-Binding Growth-Associated Molecule (HB-GAM); Heparin-Binding Growth Factor 8 (HBGF-8); Osteoblast-Specific Factor 1 (OSF-1); Neurite Outgrowth-Promoting Factor; HBNF; PTN; HBBM; HBPG; HBNF-1
EINECS	Contact for details

Quality Control

Our Pleiotrophin is produced under stringent conditions to ensure high purity and biological activity. Each batch undergoes rigorous analytical testing, including SDS-PAGE, HPLC for purity assessment, and bioactivity assays to confirm functional integrity. A comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, and biological activity is provided with every shipment to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band at ~18-20 kDa
Purity (HPLC)	≥ 95%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by cell proliferation/neurite outgrowth assay
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.