Description

(1S,4R)-2-Azabicyclo[2.2.1]Heptan-3-One CAS NO 134003-03-5 is a high-purity, chiral bicyclic lactam, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its rigid, constrained structure is essential for imparting specific stereochemistry and biological activity in final drug molecules. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutics, particularly in neurology and antiviral research.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex active pharmaceutical ingredients (APIs) and prodrugs.
• Neurological Drug Research: Used in the development of compounds targeting neurological pathways and receptors.
• Antiviral Agent Synthesis: Serves as a core scaffold for creating novel antiviral and antimicrobial agents.
• Asymmetric Catalysis: Employed as a chiral auxiliary or ligand in asymmetric synthesis to induce enantioselectivity.
• Peptidomimetics & Constrained Analogs: Integral for designing conformationally restricted peptide mimics to enhance metabolic stability and potency.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new chemical space in medicinal chemistry.

Basic Information

Product Name	(1S,4R)-2-Azabicyclo[2.2.1]Heptan-3-One
CAS No.	134003-03-5
Molecular Formula	C6H9NO
Molecular Weight	111.14 g/mol
Synonyms	(1S,4R)-(-)-2-Azabicyclo[2.2.1]heptan-3-one; (1S,4R)-3-Oxo-2-azabicyclo[2.2.1]heptane; (-)-2-Azabicyclo[2.2.1]heptan-3-one; (1S,4R)-2-Azabicyclo[2.2.1]heptan-3-one; L-2-Azabicyclo[2.2.1]heptan-3-one; (1S,4R)-3-Azabicyclo[2.2.1]heptan-2-one (tautomer); Bicyclic Lactam Derivative
EINECS	Contact for details

Quality Control

Our (1S,4R)-2-Azabicyclo[2.2.1]Heptan-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent specifications for pharmaceutical-grade intermediates. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen) after opening to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.