Description

4-Borono-2-Fluorophenylalanine is a non-natural, fluorinated amino acid derivative containing a boronic acid functional group. This compound is a critical building block in modern pharmaceutical research, particularly for the development of proteasome inhibitors and other targeted therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel drug candidates and biochemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced proteasome inhibitors, such as bortezomib analogs, for oncology research.
• Bioconjugation & Probe Development: Used to create activity-based probes (ABPs) for studying enzyme activity and function in biological systems.
• Peptidomimetic Research: Incorporated into peptide backbones to modulate stability, bioavailability, and target binding affinity.
• Boronate Affinity Chromatography: Serves as a ligand precursor for columns used in the separation of glycoproteins and cis-diol-containing compounds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical entities for drug discovery programs.
• Biochemical Tool Compound: Used in assays to investigate the mechanisms of the ubiquitin-proteasome pathway.

Basic Information

Item	Details
Product Name	4-Borono-2-Fluorophenylalanine
CAS No.	133921-60-5
Molecular Formula	C9H11BFNO4
Molecular Weight	227.00 g/mol
Synonyms	2-Fluoro-4-boronophenylalanine; (2S)-2-Amino-3-(4-borono-2-fluorophenyl)propanoic acid; Bortezomib Intermediate; 4-Boron-2-fluoro-DL-phenylalanine; 4-Dihydroxyboryl-2-fluorophenylalanine; F-Bpa; 4-Borono-2-fluoro-DL-phenylalanine; L-4-Borono-2-fluorophenylalanine
EINECS	Contact for details

Quality Control

Our 4-Borono-2-Fluorophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (L-isomer typical)
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.