Description

(S)-(+)-4-Benzyl-3-Crotonyl-2-Oxazolidinone is a high-purity, chiral oxazolidinone derivative that serves as a critical chiral auxiliary and building block in asymmetric synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, ensuring high enantiomeric purity in the final products. This compound is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to induce chirality in aldol, alkylation, and Diels-Alder reactions.
• Pharmaceutical Intermediate: Key building block for the research and development of enantiomerically pure drugs.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules in pilot plants and manufacturing.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic and medicinal chemistry laboratories.
• Fine Chemical Production: Used in the synthesis of specialty chemicals, agrochemicals, and flavors & fragrances requiring specific stereochemistry.

Basic Information

Product Name	(S)-(+)-4-Benzyl-3-Crotonyl-2-Oxazolidinone
CAS No.	133812-16-5
Molecular Formula	C₁₄H₁₅NO₃
Molecular Weight	245.27 g/mol
Synonyms	(4S)-4-Benzyl-3-[(2E)-but-2-enoyl]-1,3-oxazolidin-2-one; (S)-4-Benzyl-3-crotonyl-2-oxazolidinone; (S)-(+)-4-Benzyl-3-(2-butenoyl)-2-oxazolidinone; Evans Chiral Auxiliary Derivative; Crotonyl Evans Auxiliary; (S)-N-Crotonoyl-4-benzyl-2-oxazolidinone
EINECS	Contact for details

Quality Control

Our (S)-(+)-4-Benzyl-3-Crotonyl-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Specification available upon request
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.