Description

Surface Glycoprotein Gp46-m-2, Leishmania is a purified, recombinant protein antigen derived from the protozoan parasite Leishmania. This protein is of critical importance for research and diagnostic applications targeting leishmaniasis, a significant vector-borne tropical disease. It serves as a key reagent for scientists and diagnostic manufacturers developing immunoassays, vaccine research, and serological studies to detect and combat this infection.

Application

• Diagnostic Kit Development: Primary antigen for ELISA, immunoblot, and lateral flow assays to detect anti-Leishmania antibodies in patient sera.
• Vaccine Research: Critical component for immunological studies aimed at evaluating host immune responses and developing subunit vaccine candidates.
• Serological Studies: Used in epidemiological surveys to assess exposure and prevalence of leishmaniasis in endemic regions.
• Antibody Production & Purification: Acts as an immunogen for generating monoclonal or polyclonal antibodies specific to Leishmania Gp46.
• Biomarker Discovery: Tool for proteomic and immunoproteomic research to identify and validate disease-specific biomarkers.
• Quality Control Reference: Serves as a positive control and calibration standard for in-house diagnostic test validation and lot-to-lot consistency.

Basic Information

Product Name	Surface Glycoprotein Gp46-m-2, Leishmania
CAS No.	133655-48-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Leishmania Gp46 antigen; Glycoprotein 46; Gp46-m-2; Parasite surface antigen; Recombinant Leishmania glycoprotein; Metacyclic promastigote surface antigen; PSA-2 glycoprotein; Leishmania major glycoprotein 46
EINECS	Contact for details

Quality Control

Our Surface Glycoprotein Gp46-m-2 is manufactured under stringent conditions to ensure high purity, specificity, and batch-to-batch reproducibility suitable for critical research and diagnostic use. Each lot is rigorously characterized using a combination of analytical techniques including SDS-PAGE, Western Blot, and HPLC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, endotoxin levels, and functional activity data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted aliquots should be stored at -70°C to -80°C and avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed properly after use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Western Blot)	Reacts with specific anti-Gp46 antibody
Purity (SDS-PAGE)	> 90%
Protein Content (BCA)	> 95% of total
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in PBS or suitable aqueous buffer
Biological Activity (ELISA)	Reactive with positive control sera

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.