Description

Conantokin G CAS NO 133628-78-1 is a selective and potent antagonist of the N-methyl-D-aspartate (NMDA) receptor, specifically targeting the NR2B subunit. This compound is a valuable research-grade biochemical tool for neuroscience and pharmacological studies. It is primarily utilized by academic researchers, pharmaceutical R&D teams, and biotechnology companies investigating neurological pathways, excitotoxicity, and potential therapeutic targets for conditions like stroke, chronic pain, and neurodegenerative diseases.

Application

• Neuroscience Research: As a selective NMDA receptor antagonist for studying glutamatergic signaling, synaptic plasticity, and long-term potentiation (LTP).
• Pharmacological Profiling: Used in high-throughput screening and target validation assays to identify and characterize novel neuroprotective agents.
• Disease Mechanism Studies: Critical for modeling excitotoxicity in research related to ischemic stroke, traumatic brain injury, and epilepsy.
• Pain Research: Investigated for its role in modulating central sensitization and chronic pain pathways mediated by NMDA receptors.
• Biochemical Standard: Serves as a reference standard in analytical methods development and quality control for related peptide compounds.

Basic Information

Product Name	Conantokin G
CAS No.	133628-78-1
Molecular Formula	C95H146N34O27
Molecular Weight	2276.4 g/mol
Synonyms	Con-G; Conantokin-G; γ-Conantokin; Conantokin G from Conus geographus; NMDA receptor antagonist peptide; NR2B-selective antagonist; γ-Conantokin G
EINECS	Contact for details

Quality Control

Our Conantokin G is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, peptide content, and biological potency are available upon request, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Biological Activity (Assay)	Reported (IC50)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.