Description

Fmoc-L-Thr(β-D-Galnac(Ac)3)-Oh is a sophisticated, protected amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of glycosylated threonine residues, enabling the synthesis of complex glycopeptides. It is primarily needed by research institutions, pharmaceutical developers, and biotechnology companies engaged in advanced peptide and glycoprotein research, drug discovery, and the development of therapeutic biologics.

Application

• Glycopeptide Synthesis: A key building block for the chemical synthesis of O-linked glycopeptides, mimicking natural post-translational modifications.
• Pharmaceutical Research: Used in drug discovery programs targeting diseases where protein glycosylation plays a role, such as cancer, inflammation, and infectious diseases.
• Bioconjugation & Probe Development: Enables the site-specific incorporation of glycan motifs into peptides for creating targeted probes, vaccines, and diagnostic tools.
• Structural Biology Studies: Facilitates the production of homogeneous glycopeptides for NMR and X-ray crystallography studies to understand glycan-protein interactions.
• Synthetic Biology: Supports the generation of novel bioactive peptides with tailored glycosylation patterns for enhanced stability or specificity.

Basic Information

Product Name	Fmoc-L-Thr(β-D-Galnac(Ac)3)-Oh
CAS No.	133575-43-6
Molecular Formula	C41H48N2O17
Molecular Weight	840.83 g/mol
Synonyms	Fmoc-Thr(GalNAc(Ac)3)-OH; N-α-Fmoc-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranosyl)-L-threonine; Fmoc-L-Threonine with O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranosyl) Group; Fmoc-Thr(Ac3GalNAcα1-)-OH; Fmoc-Tn(Ac) Antigen Building Block; Glycosylated Fmoc-Threonine Derivative; Fmoc-3-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranosyl)-L-threonine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Thr(β-D-Galnac(Ac)3)-Oh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for sensitive research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.