Description

Boc-L-Thiocitrulline-Otbu is a protected derivative of the non-proteinogenic amino acid thiocitrulline, specifically designed for advanced peptide synthesis. This compound is a critical building block for researchers developing novel peptide-based therapeutics and biochemical tools. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers focused on protease inhibitor design and the study of nitric oxide synthase pathways.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of thiocitrulline into peptide chains, enabling the study of post-translational modifications like citrullination.
• Protease Inhibitor Development: Serves as a core scaffold for creating potent and selective inhibitors targeting enzymes such as calpain and other cysteine proteases.
• Nitric Oxide Synthase (NOS) Research: Used in the synthesis of substrate analogs and inhibitors to investigate the structure and function of NOS isoforms.
• Bioconjugation and Probe Synthesis: The protected functional groups allow for selective deprotection and further modification, making it suitable for creating labeled peptides or affinity probes.
• Pharmaceutical Intermediate: Employed in the research and development stages of novel therapeutic peptides targeting autoimmune and inflammatory diseases.

Basic Information

Product Name	Boc-L-Thiocitrulline-Otbu
CAS No.	133565-49-8
Molecular Formula	C₁₅H₂₈N₄O₅S
Molecular Weight	376.47 g/mol
Synonyms	tert-Butyl N-[(2S)-5-[(tert-Butoxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]pentyl]carbamothioate; (S)-2-((tert-Butoxycarbonyl)amino)-5-((tert-butoxycarbonyl)amino)pentyl carbamothioate; Boc-Thiocitrulline-OtBu; Nα-Boc-Nδ-Boc-L-thiocitrulline tert-butyl ester; Thiocitrulline derivative, Boc-protected; L-Thiocitrulline, N2-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our Boc-L-Thiocitrulline-Otbu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	-20.0° to -24.0° (c=1 in Methanol)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.