Description

(S)-(-)-2,2'-Bis(Di-p-Tolylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bidentate phosphine ligand, a member of the privileged MeO-BIPHEP family. This compound matters for its exceptional ability to induce high enantioselectivity in asymmetric catalytic transformations, a critical factor for producing single-enantiomer pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance ligands for transition metal catalysis.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids, amines, and other pharmaceutical intermediates.
• Catalyst component in asymmetric C-C bond-forming reactions, including cross-coupling and allylic substitution.
• Critical for process development and scale-up of Active Pharmaceutical Ingredients (APIs) requiring high optical purity.
• Research and development of novel homogeneous catalysts for academic and industrial discovery programs.
• Used in the synthesis of agrochemicals and flavors & fragrances where chiral control is essential.
• Preparation of metal-ligand complexes for mechanistic studies and catalyst optimization.

Basic Information

Product Name	(S)-(-)-2,2'-Bis(Di-p-Tolylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	133545-25-2
Molecular Formula	C46H44O2P2
Molecular Weight	690.78 g/mol
Synonyms	(S)-(-)-2,2'-Bis(di-p-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl; (S)-(-)-MeO-BIPHEP; (S)-2,2'-Bis(di-4-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl; (S)-DTBM-MeO-BIPHEP; (S)-(-)-DTBM-MeO-BIPHEP; (S)-6,6'-Dimethoxy-2,2'-bis(di-p-tolylphosphino)-1,1'-biphenyl; LICHEM Ligand (S)-MeO-BIPHEP; Chiral Bidentate Phosphine Ligand (S)-(-)-MeO-BIPHEP
EINECS	Contact for details

Quality Control

Our (S)-(-)-MeO-BIPHEP is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity are provided to support your GMP and R&D documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Enantiomeric Excess (ee)	Min. 99.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.