Description

(R)-(+)-2,2'-Bis(Di-p-Tolylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand, a member of the privileged MeO-Biphep family. This compound matters for its exceptional ability to induce high enantioselectivity in asymmetric catalytic transformations, a critical factor in the synthesis of single-enantiomer pharmaceuticals and fine chemicals. Industrial chemists and R&D teams in pharmaceutical development, agrochemical manufacturing, and advanced material science require this ligand to achieve superior product purity and process efficiency. Its defined stereochemistry and high ligand purity are essential for reproducible and scalable catalytic performance.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, particularly in the synthesis of chiral amino acids, pharmaceutical intermediates, and natural products.
• Pharmaceutical Intermediate Synthesis: Critical for constructing stereogenic centers in active pharmaceutical ingredients (APIs) for cardiovascular, central nervous system, and antiviral drugs.
• Asymmetric C-C Bond Formation: Employed in Rhodium or Ruthenium-catalyzed asymmetric allylic alkylation, hydroformylation, and conjugate addition reactions.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Catalyst Screening & Development: A standard ligand in high-throughput screening (HTS) kits and for the development of proprietary catalytic processes in fine chemical manufacturing.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research within university and corporate laboratories.

Basic Information

Item	Details
Product Name	(R)-(+)-2,2'-Bis(Di-p-Tolylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	133545-24-1
Molecular Formula	C46H44O2P2
Molecular Weight	698.78 g/mol
Synonyms	(R)-MeO-Biphep; (R)-(+)-2,2'-Bis(di-p-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl; (R)-6,6'-Dimethoxy-2,2'-bis(di-p-tolylphosphino)-1,1'-biphenyl; (R)-DTBM-MeO-BIPHEP; (R)-(+)-DTBM-MeO-BIPHEP; (R)-Bisphosphine MeO-Biphep Derivative; Ligand (R)-L1; (R)-BIPHEMP Derivative
EINECS	Contact for details

Quality Control

Every batch of our (R)-MeO-Biphep ligand is produced and tested under strict quality management protocols to ensure consistent high purity and chiral integrity, which are non-negotiable for catalytic performance. We employ advanced analytical techniques including HPLC, NMR, and chiral analysis to verify identity, assay, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and moisture-sensitive; therefore, the container should be flushed with inert gas after each opening and stored in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.