Description

S(-)-2 2-Bis-(Diphenylphosphino)-6 6-Dim is a high-value chiral phosphine ligand, a critical component in asymmetric catalysis. Its precise stereochemistry enables the production of enantiomerically pure intermediates, which is essential for developing advanced pharmaceuticals and fine chemicals. This ligand is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel synthetic pathways and optimizing existing ones.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical API synthesis.
• Cross-Coupling Reactions: Used in asymmetric versions of Suzuki, Heck, and Negishi couplings to construct chiral biaryl and other complex molecular frameworks.
• Pharmaceutical Intermediate Synthesis: Critical for the production of single-enantiomer drug candidates targeting central nervous system, cardiovascular, and oncological diseases.
• Agrochemical Development: Employed in the synthesis of chiral herbicides, fungicides, and plant growth regulators with enhanced activity and environmental profile.
• Academic & Industrial Research: A valuable tool for methodology development in organic synthesis and catalysis research laboratories.
• Fine Chemical Manufacturing: Facilitates the production of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Item	Detail
Product Name	S(-)-2 2-Bis-(Diphenylphosphino)-6 6-Dim
CAS No.	133545-17-2
Molecular Formula	C32H28P2
Molecular Weight	474.51 g/mol
Synonyms	(S)-(-)-2,2'-Bis(diphenylphosphino)-6,6'-dimethoxy-1,1'-biphenyl; (S)-BIPHEP-OMe; (S)-(-)-2,2'-Bis(diphenylphosphino)-6,6'-dimethoxybiphenyl; (S)-6,6'-Dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl; (S)-(-)-6,6'-DimethoxyBIPHEP; (S)-MeOBIPHEP; L009
EINECS	Contact for details

Quality Control

Our production of S(-)-2 2-Bis-(Diphenylphosphino)-6 6-Dim adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is fully characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (ee), and identity is provided with every shipment, supporting cGMP and ISO quality management system requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.