Description

125I-Sap is a high-specific-activity, radioiodinated derivative of the potent ribosome-inactivating protein, saporin. This compound is a critical tool for targeted cytotoxicity studies, enabling precise ablation of specific cell populations via antigen recognition. It is primarily utilized by researchers and developers in the life sciences sector for applications in neuroscience, immunology, and oncology. The product is supplied with guaranteed radiochemical purity and specific activity to ensure reliable and reproducible experimental results.

Application

• Targeted Cell Ablation (Immunotoxins): Conjugation to antibodies or ligands for the selective elimination of specific cell types in research models.
• Neuroscience Research: Used in conjunction with targeted conjugates (e.g., 125I-Saporin conjugated to substance P or anti-DβH antibodies) for selective lesioning of neuronal pathways.
• Cancer Research & Therapy Development: Evaluation of novel antibody-drug conjugate (ADC) constructs and targeted radiotherapy approaches.
• Immunology Studies: Depletion of specific immune cell subsets to study their function in disease models.
• Pharmacokinetic & Biodistribution Studies: Radiolabel allows for precise tracking of conjugate localization and clearance in vivo.
• Quality Control for Bioconjugates: Serves as a reference standard in the development and validation of targeted therapeutic agents.

Basic Information

Product Name	125I-Sap
CAS No.	133538-59-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Iodine-125 Labeled Saporin; [125I]-Saporin; Saporin, 125I-labeled; Radioiodinated Saporin; 125I-Saporin; Targeted Toxin 125I-Sap; Ribosome-Inactivating Protein, 125I-; Anti-DβH-SAP (when conjugated)
EINECS	Contact for details

Quality Control

Every batch of 125I-Sap is manufactured and controlled under a strict quality management system. Rigorous analytical testing is performed to ensure high radiochemical purity and consistent specific activity, which are critical for experimental reproducibility. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for key parameters including purity, activity, and sterility (where applicable). Our quality commitment supports research compliance with GLP (Good Laboratory Practice) standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the product should be kept in a dry environment. For long-term storage, consider conditions as recommended on the specific batch COA. Handle all radioactive materials in accordance with local radiation safety regulations.

Specification

Item	Specification
Appearance	Clear solution
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	~ 2200 Ci/mmol (Contact for batch-specific value)
Radionuclidic Purity	≥ 99%
Concentration	Specified on COA (e.g., μCi/μL)
Buffer/Formulation	Phosphate Buffered Saline, pH ~7.4
Sterility (if claimed)	Sterile Filtered

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.