Description

3'-Azido-3'-Deoxythymidine β-D-Glucuronide, Sodium Salt is a key metabolite and reference standard of the antiviral drug Zidovudine (AZT). This compound is essential for pharmacokinetic and metabolic studies, providing critical insights into drug behavior and clearance pathways. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on antiviral drug development and analytical method validation.

Application

• Metabolite Reference Standard for the quantitative analysis of Zidovudine (AZT) and its metabolites in biological matrices.
• Pharmacokinetic Studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of AZT.
• Analytical Method Development and Validation for HPLC, LC-MS, and other chromatographic techniques in bioanalytical laboratories.
• Drug Metabolism Research investigating Phase II conjugation pathways, specifically glucuronidation.
• Quality Control in the manufacturing of antiviral pharmaceuticals to ensure batch consistency and purity.
• Toxicology Studies to assess the safety and metabolic fate of AZT and related nucleoside analogs.

Basic Information

Product Name	3'-Azido-3'-Deoxythymidine β-D-Glucuronide, Sodium Salt
CAS No.	133525-01-6
Molecular Formula	C16H20N5NaO10
Molecular Weight	465.35 g/mol
Synonyms	AZT Glucuronide Sodium Salt; Zidovudine Glucuronide Sodium Salt; 3'-Azido-3'-deoxythymidine Glucuronide Sodium Salt; AZT-β-D-Glucuronide Sodium; 1-((2R,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)-1-deoxy-β-D-glucopyranuronic Acid Sodium Salt; Glucuronide Metabolite of Zidovudine (Sodium Salt)
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxythymidine β-D-Glucuronide, Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for reference material and research use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Assay (HPLC)	≥90.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.