Description

1,3-Benzenedicarboxamide, N,N'-Bis(2,3-Dihydroxypropyl)-5-[(Hydroxyacetyl)(2-Hydroxyethyl)Amino]-2,4,6-Triiodo-, (R*,R*)-(+-)- is a high-purity, non-ionic iodinated contrast agent intermediate. This compound is critical for its role in enhancing X-ray imaging clarity and safety in diagnostic medicine. It is primarily required by pharmaceutical manufacturers and advanced chemical synthesis facilities developing next-generation contrast media for computed tomography (CT) and angiography.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of modern, low-osmolar, non-ionic X-ray contrast agents like Iopamidol and Ioversol.
• Diagnostic Imaging: Used in the production of contrast media for enhanced visualization of blood vessels, organs, and tissues in CT scans.
• Medical Research: Serves as a precursor in R&D for novel iodinated compounds with improved pharmacokinetic profiles and reduced side effects.
• Contrast Media Formulation: Integral to formulating sterile, injectable solutions with high tolerability and optimal radiopacity.
• Chemical Synthesis: Employed in organic synthesis for introducing triiodinated benzene cores with specific hydrophilic side chains.
• Quality Control Standards: Can be utilized as a reference standard in analytical laboratories for method development and impurity profiling.

Basic Information

Product Name	1,3-Benzenedicarboxamide, N,N'-Bis(2,3-Dihydroxypropyl)-5-[(Hydroxyacetyl)(2-Hydroxyethyl)Amino]-2,4,6-Triiodo-, (R*,R*)-(+-)-
CAS No.	133443-72-8
Molecular Formula	C19H27I3N3O8
Molecular Weight	791.05 g/mol
Synonyms	5-[N-(2-Hydroxyacetyl)-N-(2-hydroxyethyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; Iopamidol Impurity; Iopamidol Related Compound; Ioversol Intermediate; Non-ionic Contrast Agent Intermediate; Triiodinated Isophthalamide Derivative; (R*,R*)-(±)-Isomer of Iopamidol Precursor
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines. Every batch undergoes comprehensive analytical testing, including HPLC for purity and impurity profiling, to ensure it meets the exacting standards required for drug substance synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, assay, and limits for specified impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.