Description

Human Cntf CAS NO 133423-39-9 is a high-purity recombinant protein, specifically Ciliary Neurotrophic Factor, essential for advanced biomedical research and therapeutic development. This critical cytokine plays a vital role in the survival and differentiation of neuronal and glial cells, making it a key reagent for studying neurological disorders and nerve regeneration. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neurobiology, cell culture, and the development of novel biopharmaceuticals.

Application

• Neuroscience Research: Fundamental studies on neuronal survival, differentiation, and axonal growth in both in vitro and in vivo models.
• Cell Culture & Stem Cell Biology: Used as a growth factor component in media for maintaining and differentiating neural stem cells and other sensitive cell lines.
• Drug Discovery & Screening: Serves as a target or tool compound in high-throughput screening assays for identifying potential neuroprotective or neuroregenerative agents.
• Biopharmaceutical Development: Critical for the research and development phase of protein-based therapeutics targeting conditions like amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.
• Diagnostic Reagent Production: Used in the development and calibration of immunoassays and diagnostic kits for neurological markers.

Basic Information

Product Name	Human Cntf
CAS No.	133423-39-9
Molecular Formula	C860H1353N233O255S9
Molecular Weight	~22.8 kDa
Synonyms	Ciliary Neurotrophic Factor; CNTF; Human CNTF; Recombinant Human Ciliary Neurotrophic Factor; rhCNTF; Axokine; HCNTF; Neurotrophic Factor, Ciliary; Gliosis-Inhibiting Factor
EINECS	Contact for details

Quality Control

Our Human Cntf is manufactured under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, and biological potency. We adhere to relevant quality management systems to guarantee batch-to-batch consistency and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted protein solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use in a low-humidity environment.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Purity (HPLC)	> 98%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by cell-based assay (TF-1 or similar)
Solubility	Soluble in water or PBS
Identification (Mass Spec)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.