Description

Fmoc-His(Mtt)-Oh CAS NO 133367-34-7 is a protected derivative of the amino acid histidine, specifically designed for use in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers who require precise control over the synthesis of complex peptides, particularly those containing histidine residues. It is an essential building block for pharmaceutical R&D, biotechnology, and the production of therapeutic peptides and APIs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the sequential assembly of peptide chains on resin.
• Pharmaceutical Research: Used in the development and synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a precursor for creating peptide-protein conjugates or labeled peptides for diagnostic and research applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the synthesis of peptide linkers or payload components in targeted cancer therapies.
• Academic & Industrial R&D: A fundamental reagent for studying protein structure-function relationships and peptide hormone analogs.

Basic Information

Product Name	Fmoc-His(Mtt)-Oh
CAS No.	133367-34-7
Molecular Formula	C41H39N3O5
Molecular Weight	653.77 g/mol
Synonyms	Fmoc-His(Mtt)-OH; N-α-Fmoc-N-π-Mtt-L-histidine; Fmoc-L-histidine(Mtt)-OH; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(4-methylphenyl)diphenylmethyl]-L-histidine; Fmoc-His(4-Methyltrityl)-OH; Fmoc-His(Mtt); Fmoc-Histidine(Mtt)-OH; Nim-Mtt-Nα-Fmoc-L-histidine
EINECS	Contact for details

Quality Control

Our Fmoc-His(Mtt)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.