Description

(S)-3-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-2-Hydroxy-Propionic Acid is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in advanced asymmetric synthesis and active pharmaceutical ingredient (API) development.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of novel drug candidates, particularly those targeting specific enantiomeric activity.
• Asymmetric Synthesis: Used as a starting material or reagent in stereoselective chemical reactions to construct complex molecular architectures with high optical purity.
• Protease Inhibitor Research: Serves as a core structural component in the research and development of enzyme inhibitors, due to its hydroxypropionic acid moiety linked to a phthalimide group.
• Peptidomimetics: Incorporated into the design of peptide-like compounds that mimic the structure and function of natural peptides for therapeutic applications.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and protein functions.
• Custom Synthesis & CDMO Projects: Supplied to contract research and manufacturing organizations for use in client-specific development and scale-up campaigns.

Basic Information

Product Name	(S)-3-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-2-Hydroxy-Propionic Acid
CAS No.	133319-36-5
Molecular Formula	C11H9NO5
Molecular Weight	235.19 g/mol
Synonyms	(S)-2-Hydroxy-3-(1,3-dioxoisoindolin-2-yl)propanoic acid; (S)-N-Phthaloyl-3-hydroxyalanine; L-N-Phthaloyl-3-hydroxyalanine; (S)-3-Hydroxy-2-phthalimidopropionic acid; 2-[(2S)-2-Hydroxy-1-carboxyethyl]isoindole-1,3-dione; (S)-HPA; (S)-3-(1,3-Dioxoisoindolin-2-yl)-2-hydroxypropanoic acid; (S)-3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxypropanoic acid
EINECS	Contact for details

Quality Control

Our (S)-3-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-2-Hydroxy-Propionic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and impurity profiles. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.