Description

Ethyl 2,2,3,3-Tetrafluoropropionylacetate is a high-value fluorinated building block and reagent, essential for introducing the tetrafluoropropionyl moiety into complex molecules. Its unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) with enhanced properties. This compound is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise fluorination.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated pesticides and herbicides to improve efficacy and environmental profile.
• Material Science: Serves as a monomer or precursor for fluorinated polymers, coatings, and specialty materials with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Acts as a versatile reagent in nucleophilic acyl substitution and condensation reactions to introduce fluorinated acetyl groups.
• Liquid Crystal & Electronic Chemicals: Potential intermediate in the synthesis of fluorinated liquid crystals and electronic chemicals for display and semiconductor industries.
• Research & Development: A valuable tool for medicinal chemistry and process chemistry research exploring the effects of fluorination on molecular properties.

Basic Information

Product Name	Ethyl 2,2,3,3-Tetrafluoropropionylacetate
CAS No.	133291-73-3
Molecular Formula	C7H8F4O3
Molecular Weight	216.13 g/mol
Synonyms	Ethyl 3-oxo-4,4,5,5-tetrafluoropentanoate; 4,4,5,5-Tetrafluoro-3-oxopentanoic acid ethyl ester; Ethyl 4,4,5,5-tetrafluoro-3-oxopentanoate; 2,2,3,3-Tetrafluoropropionylacetic acid ethyl ester; Ethyl (tetrafluoropropionyl)acetate; Acetic acid, 2,2,3,3-tetrafluoropropionyl-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2,2,3,3-Tetrafluoropropionylacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.