Description

3-o-(2-Cyanoethyl)-25-Hydroxyvitamin D3 is a chemically modified derivative of vitamin D, specifically designed as a key synthetic intermediate. This compound matters for its critical role in the efficient, multi-step synthesis of advanced vitamin D analogs and active pharmaceutical ingredients (APIs). Pharmaceutical research and development laboratories, as well as fine chemical manufacturers, need this high-purity intermediate to produce novel therapeutics targeting calcium metabolism and related disorders.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of advanced vitamin D analogs and active metabolites for drug development.
• Research Chemical: Serves as a crucial building block in academic and industrial research exploring vitamin D receptor (VDR) modulators.
• Process Development: Used in scaling up and optimizing synthetic routes for the production of calcitriol and related compounds.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for quality control in API manufacturing.
• Biochemical Probe: Employed in studies to understand the structure-activity relationships (SAR) of vitamin D derivatives.

Basic Information

Product Name	3-o-(2-Cyanoethyl)-25-Hydroxyvitamin D3
CAS No.	133191-10-3
Molecular Formula	C₂₉H₄₅NO₂
Molecular Weight	439.68 g/mol
Synonyms	3-O-(2-Cyanoethyl)calcidiol; 25-Hydroxy-3-O-(2-cyanoethyl)vitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3β-ol, 25-hydroxy-, 3-(2-cyanoethyl) ether; 25-Hydroxycholecalciferol 3-(2-cyanoethyl) ether; Vitamin D3 derivative, 3-cyanoethylated; 3β-[(2-Cyanoethoxy)]-25-hydroxy-9,10-secocholesta-5,7,10(19)-triene
EINECS	Contact for details

Quality Control

Our 3-o-(2-Cyanoethyl)-25-Hydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. The container must be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.