Description

Cefepime CAS NO 133162-90-0 is a fourth-generation, broad-spectrum cephalosporin antibiotic belonging to the β-lactam class. It is valued for its enhanced stability against β-lactamase enzymes and potent activity against a wide range of Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. This makes it a critical active pharmaceutical ingredient (API) for the formulation of injectable antibiotics used in hospital settings to treat serious infections such as pneumonia, bacteremia, and febrile neutropenia.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for intravenous or intramuscular administration.
• Hospital-Acquired Infections: Treatment of complicated infections including nosocomial pneumonia, urinary tract infections (UTIs), and skin/soft tissue infections.
• Empiric Therapy: Used in febrile neutropenia patients and for empiric treatment of severe infections where the causative organism is unknown.
• Combination Therapy: May be used in conjunction with other antimicrobial agents for synergistic effects in treating multi-drug resistant organisms.
• Veterinary Medicine: Potential application in treating serious bacterial infections in companion and livestock animals under veterinary guidance.
• Research & Development: Serves as a reference standard and key intermediate in pharmaceutical R&D for developing new antibiotic formulations and combination therapies.

Basic Information

Product Name	Cefepime
CAS No.	133162-90-0
Molecular Formula	C19H24N6O5S2
Molecular Weight	480.56 g/mol
Synonyms	1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium; BMY-28142; Cefepime Dihydrochloride Monohydrate; Axepim; Maxipime; Cefepime HCl; Cefepime Hydrochloride
EINECS	Contact for details

Quality Control

Our Cefepime is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Quality is assured through comprehensive analytical testing, including HPLC for purity and related substances, identification by IR and NMR, and tests for residual solvents and heavy metals. We can supply material compliant with major pharmacopoeial standards such as USP and EP. A Certificate of Analysis (COA) is provided with each batch to guarantee specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
pH (1% solution)	3.5 - 5.5
Specific Optical Rotation	+39° to +45°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.