Description

7-(-2-(2-Aminothiazol-4-Yl)-2-(3-(3-Hydroxy-4-Pyridon-1-Yl)-3-Carboxypropoxyimino)Acetamido)-3-(1,2,3-Thiadiazol-5-Yl)-Thiomethyl-3-Cephem-4-Carboxylic Acid CAS NO 133162-45-5 is a complex, advanced-generation cephalosporin intermediate with a sophisticated molecular structure designed for potent antibacterial activity. This compound is of critical importance for the research and development of novel antibiotics, particularly those targeting resistant bacterial strains. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in the synthesis of next-generation β-lactam antibiotics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced cephalosporin antibiotics.
• Antibacterial Research: Used in R&D for developing new drugs with activity against Gram-positive and Gram-negative bacteria.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aiming to optimize the efficacy and spectrum of β-lactam compounds.
• Fine Chemical Synthesis: Serves as a high-value precursor in multi-step organic syntheses for specialized chemical libraries.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for quality control in API (Active Pharmaceutical Ingredient) manufacturing.

Basic Information

Product Name	7-(-2-(2-Aminothiazol-4-Yl)-2-(3-(3-Hydroxy-4-Pyridon-1-Yl)-3-Carboxypropoxyimino)Acetamido)-3-(1,2,3-Thiadiazol-5-Yl)-Thiomethyl-3-Cephem-4-Carboxylic Acid
CAS No.	133162-45-5
Molecular Formula	C24H22N8O9S3
Molecular Weight	662.67 g/mol
Synonyms	(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[[(3S)-3-carboxy-3-(3-hydroxy-4-oxo-1-pyridinyl)propoxy]imino]acetyl]amino]-3-[(1,2,3-thiadiazol-5-ylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephalosporin derivative with thiadiazolethio and aminothiazole oxime side chains; Advanced cephalosporin nucleus; 7-ACA derivative intermediate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We adhere to strict protocols suitable for pharmaceutical intermediate applications, with a focus on identity, purity, and impurity profile control. Certificates of Analysis (COA) detailing batch-specific results for key parameters are available upon request. Specifications can be aligned with customer requirements for research or GMP (Good Manufacturing Practice) applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.