Description

Hemoglobin Iowa CAS NO 133108-59-5 is a specific, naturally occurring variant of hemoglobin, a critical oxygen-transporting metalloprotein found in red blood cells. This compound is of significant value in biochemical research and diagnostic development due to its unique structural properties that differentiate it from normal adult hemoglobin (HbA). It is primarily utilized by research institutions, clinical diagnostic manufacturers, and biotechnology companies engaged in hematology studies, hemoglobinopathy research, and the calibration of analytical instruments.

Application

• Biochemical Research: Used as a reference standard in studies of hemoglobin structure, function, and genetic variants.
• Diagnostic Development: Serves as a critical component in the manufacturing and calibration of diagnostic assays and kits for detecting hemoglobin disorders.
• Hematology Standards: Employed in the formulation of quality control materials and calibrators for clinical laboratory analyzers.
• Pharmaceutical Research: Investigated in preclinical research for potential therapeutic applications related to oxygen delivery.
• Educational Purposes: Used in academic settings for teaching advanced concepts in protein chemistry and human genetics.

Basic Information

Product Name	Hemoglobin Iowa
CAS No.	133108-59-5
Molecular Formula	C2952H4664N812O840S8Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Iowa; Hemoglobin variant Iowa; HBB: c.206 T>C; Hemoglobin β-chain variant Iowa; Hemoglobin (human β206 Phe→Ser); Unstable Hemoglobin Iowa; Hemoglobin Philly-Iowa; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Hemoglobin Iowa is produced and handled under stringent quality protocols. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, spectral analysis, and functional characterization, to ensure it meets the exacting standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95% (Hb Iowa)
Assay (Functional)	≥ 90% of theoretical oxygen binding capacity
Methemoglobin Content	≤ 5%
Water Content (KF)	≤ 3.0%
Biological Activity	Confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.