Description

4-Bromo-3-Fluorobenzonitrile is a versatile halogenated benzonitrile derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on the aromatic ring, makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides where the bromo-fluoro substitution pattern influences bioactivity.
• Ligand and Material Science: Used in the preparation of specialized ligands for catalysis and as a monomer or precursor for advanced polymeric materials and liquid crystals.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the reactive bromine atom.
• Chemical Research & Development: Essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: A valuable compound for introducing fluorine atoms into complex molecular architectures, leveraging the fluorine atom's unique properties.

Basic Information

Product Name	4-Bromo-3-Fluorobenzonitrile
CAS No.	133059-44-6
Molecular Formula	C7H3BrFN
Molecular Weight	200.01 g/mol
Synonyms	3-Fluoro-4-bromobenzonitrile; 4-Bromo-3-fluorobenzene carbonitrile; 1-Bromo-2-fluoro-4-cyanobenzene; Benzonitrile, 4-bromo-3-fluoro-; 4-Cyano-2-fluorobromobenzene; 2-Fluoro-4-cyanobromobenzene; 4-Bromo-3-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	65 - 70 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.