Description

4-Fluorophenyl Trifluoromethanesulphonate is a high-purity organosulfur reagent featuring a reactive triflate leaving group on a fluorinated aromatic ring. This compound is a critical building block in advanced organic synthesis, enabling efficient cross-coupling reactions and functional group transformations. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and specialty materials industries for the development of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated aryl ethers or sulfonamides.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides where the 4-fluorophenyl moiety imparts desirable biological activity and metabolic stability.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed reactions such as Suzuki-Miyaura, Stille, and Negishi couplings to form biaryl structures.
• Ligand and Catalyst Preparation: Employed in the functionalization of phosphines, amines, and other ligands to create sophisticated catalytic systems for asymmetric synthesis.
• Material Science Research: Used to incorporate fluorinated aromatic units into polymers, liquid crystals, and organic electronic materials to modify their physical properties.
• Chemical Biology Probes: Acts as a reagent for labeling and modifying biomolecules in the development of diagnostic tools and research probes.

Basic Information

Product Name	4-Fluorophenyl Trifluoromethanesulphonate
CAS No.	132993-23-8
Molecular Formula	C7H4F4O3S
Molecular Weight	244.16 g/mol
Synonyms	4-Fluorophenyl Triflate; 1-Fluoro-4-(trifluoromethanesulfonyloxy)benzene; p-Fluorophenyl Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid 4-Fluorophenyl Ester; 4-Fluorophenyl Trifluoromethylsulfonate; 4-Fluoro-1-(trifluoromethanesulfonyloxy)benzene; 4-Fluoro Phenyl Triflate
EINECS	Contact for details

Quality Control

Our 4-Fluorophenyl Trifluoromethanesulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available for every lot to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.