Description

2,3,5-Trifluorophenylacetic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethylphenyl moiety imparts desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport materials and emitters for high-efficiency displays.
• Advanced Polymer Chemistry: Acts as a monomer or modifier to introduce fluorine into polymers, improving chemical resistance and surface properties.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and creating compound libraries for screening.

Basic Information

Product Name	2,3,5-Trifluorophenylacetic Acid
CAS No.	132992-28-0
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	(2,3,5-Trifluorophenyl)acetic Acid; 2-(2,3,5-Trifluorophenyl)acetic Acid; α-(2,3,5-Trifluorophenyl)acetic Acid; 2,3,5-Trifluorobenzeneacetic Acid; 2,3,5-Trifluoro-α-toluic Acid; TL-1-178; BRN 2932693; ZINC000257049503
EINECS	Contact for details

Quality Control

Our 2,3,5-Trifluorophenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can supply material compliant with cGMP standards for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.