Description

Tyk2 Protein CAS NO 132966-45-1 is a recombinant protein corresponding to the tyrosine kinase 2 enzyme, a critical component of the Janus kinase (JAK) family involved in cytokine signaling pathways. This high-purity protein is essential for biochemical and pharmaceutical research, particularly in the study of autoimmune diseases, inflammatory conditions, and oncology. It serves as a vital reagent for researchers and developers in drug discovery, target validation, and high-throughput screening applications, providing a reliable tool for understanding disease mechanisms and developing novel therapeutics.

Application

• Drug Discovery & High-Throughput Screening (HTS): Used as a primary target in assays to identify and characterize novel Tyk2 inhibitors for therapeutic development.
• Biochemical & Enzymatic Assays: Serves as a key reagent for studying kinase activity, enzyme kinetics, and inhibitor potency in vitro.
• Autoimmune & Inflammatory Disease Research: Critical for investigating the role of the JAK-STAT signaling pathway in conditions like psoriasis, rheumatoid arthritis, and inflammatory bowel disease.
• Oncology Research: Utilized in studies exploring the involvement of Tyk2 in cancer cell proliferation and survival signaling.
• Structural Biology & Crystallography: Provides purified protein for 3D structure determination and analysis of inhibitor binding sites.
• Antibody & Diagnostic Development: Acts as an antigen for the production and validation of specific antibodies and assay components.
• Selectivity Profiling: Employed in panels to assess the selectivity of kinase inhibitors against Tyk2 compared to other kinases.
• Academic & Contract Research: Supports fundamental research in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	Tyk2 Protein
CAS No.	132966-45-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tyrosine Kinase 2 Protein; TYK2 Kinase; JAK1-like Protein Kinase; Non-Receptor Tyrosine-Protein Kinase TYK2; p134 Tyrosine Kinase; Tyrosine Kinase p134TYK2; EC 2.7.10.2; TYK2 (full length); Recombinant Human Tyk2 Protein
EINECS	Contact for details

Quality Control

Our Tyk2 Protein is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, confirmation of identity, and functional activity assays. A Certificate of Analysis (COA) detailing specific results for purity, concentration, activity, and endotoxin levels is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	≥ 90%
Identification (Western Blot)	Positive
Biological Activity	Determined by functional kinase assay
Protein Concentration	As per COA
Endotoxin Level	< 1.0 EU/µg (for cell-based applications)
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.