Description

Fmoc-D-Penicillamine CAS NO 132930-71-3 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise stereochemical control and efficient deprotection in the construction of complex peptides and peptidomimetics. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for drug discovery, development of therapeutic peptides, and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing the D-penicillamine residue with Fmoc (9-fluorenylmethoxycarbonyl) protection.
• Pharmaceutical Research: Synthesis of novel peptide-based drug candidates, enzyme inhibitors, and receptor ligands.
• Bioconjugation: Preparation of modified peptides for antibody-drug conjugates (ADCs) or diagnostic probes.
• Material Science: Incorporation into self-assembling peptide scaffolds and biomaterials.
• Chemical Biology: Tool compound for studying metal-binding properties and redox activity in peptides.
• Process Development: Scaling up the production of peptides containing non-proteinogenic amino acids for clinical trials.

Basic Information

Product Name	Fmoc-D-Penicillamine
CAS No.	132930-71-3
Molecular Formula	C₂₀H₂₁NO₄S
Molecular Weight	371.45 g/mol
Synonyms	Fmoc-D-Pen-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-penicillamine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoic acid; D-Penicillamine, N-Fmoc derivative; Fmoc-D-β,β-dimethylcysteine; N-Fmoc-D-penicillamine; Fmoc-D-Pen
EINECS	Contact for details

Quality Control

Our Fmoc-D-Penicillamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for peptide synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere (argon or nitrogen) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.