Description

n-Hexadecanoyl-D-Valine is a high-purity, synthetic amino acid derivative where palmitic acid is conjugated to the D-isomer of valine. This compound matters as a critical chiral building block and intermediate for the research and development of novel pharmaceuticals, particularly in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs). It is needed by R&D chemists, process development scientists, and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new therapeutic entities with specific stereochemical configurations.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation Research: Used in the development of lipidated peptides and protein conjugates to modify pharmacokinetic properties.
• Asymmetric Synthesis: Serves as a building block for constructing complex molecules with defined stereochemistry in medicinal chemistry.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Cosmetic Peptide Synthesis: Potential intermediate for the production of bioactive peptides used in advanced skincare formulations.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	n-Hexadecanoyl-D-Valine
CAS No.	132869-86-4
Molecular Formula	C₂₁H₄₁NO₃
Molecular Weight	355.56 g/mol
Synonyms	Palmitoyl-D-valine; D-Valine, N-(1-oxohexadecyl)-; Hexadecanoyl-D-valine; N-Palmitoyl-D-valine; (R)-2-(Hexadecanamido)-3-methylbutanoic acid; N-(1-Oxohexadecyl)-D-valine; Palmitic acid-D-valine conjugate
EINECS	Contact for details

Quality Control

Our n-Hexadecanoyl-D-Valine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.