Description

Rufloxacin Sulfoxide is a key pharmaceutical intermediate and metabolite of the fluoroquinolone antibiotic Rufloxacin. This compound is critical for research and development in the pharmaceutical sector, particularly for studying drug metabolism, pharmacokinetics, and for use as a reference standard in analytical testing. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in antibiotic development and quality control.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis and research of advanced fluoroquinolone antibiotics.
• Metabolite Reference Standard: Used as an analytical standard in HPLC, LC-MS, and other chromatographic methods for the identification and quantification of Rufloxacin metabolites in biological and pharmaceutical samples.
• Pharmacokinetic & Metabolic Studies: Essential for in-vitro and in-vivo research to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Rufloxacin.
• Impurity Profiling: Employed in the quality control of Rufloxacin API to identify, monitor, and control related substance impurities.
• Bioanalytical Research: Supports method development and validation in clinical and pre-clinical studies for accurate drug level monitoring.

Basic Information

Product Name	Rufloxacin Sulfoxide
CAS No.	132843-25-5
Molecular Formula	C17H19FN4O4S
Molecular Weight	410.42 g/mol
Synonyms	9-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid 5-oxide; Rufloxacin S-Oxide; Rufloxacin Sulfone; MF 934 Sulfoxide; 132843-25-5; Rufloxacin Metabolite; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid sulfoxide
EINECS	Contact for details

Quality Control

Our Rufloxacin Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and related substance analysis, to ensure it meets high-purity standards suitable for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.